A variety of HPV tests can be used to detect HPV genotypes and determine a woman’s risk of developing cervical precancer and cancer. Current FDA approved HPV tests can be divided into two categories: assays with partial genotyping & assays with extended genotyping.1,2

 

  • HPV assays with partial genotyping report HPV 16 and 18 or 18/45 separately and the remaining high-risk genotypes in a single, pooled result3
  • HPV assays with extended genotyping detect and report at least 5 individual high-risk HPV genotypes1-6
PARTIAL GENOTYPING EXTENDED GENOTYPING 18 18 31 16 51 52 45 16 31 ? 68 ? 59 ? 52 ? 66 ? 56 ? 39 ? 45 ? 51 ? 51 ? 35 ? 33 ? 68 ? 39 ? 35 ? 59 ? 56 ? 66 ? 58 ? 33 ? Individual results Pooled results
HPV assays
with extended genotyping

There are 14 most clinically relevant hr-HPV genotypes, and partial genotyping reports many of these genotypes in a single result with a pooled group.1,2

HPV Genotype   HPV Test result 1
HPV 16   Negative
HPV 18, 45   Negative
HPV 31, 33, 35, 39, 51, 52, 56, 58, 59, 59, 66, 68   Positive

With partial genotyping, a positive result for the pooled group could indicate infection with HPV 31, which has a similar risk of developing into cervical cancer as HPV 18,1,2,6-10 or it could mean an infection with HPV 51, which has a much lower risk of developing into cervical cancer.7

HPV 31

Partial genotyping can mask the true risk of cervical precancer and cancer and prevent effective monitoring of HPV infections1

FDA, Food and Drug Administration; HPV, human papillomavirus; hr, high-risk

1. Bonde JH et al. J Low Genit Tract Dis. 2020;24(1):1-13
2. Salazar KL et al. J Am Soc Cytopathol. 2019;8(5):284-292
3. Bonde J et al. J Clin Virol. 2018;108:64-71
4. Brady MT et al. Pediatrics. 2012;129(3):602-5
5. Meites E et al. CDC, Human Papillomavirus. Accessed 4 Nov 2021.
6. Perkins RB et al. J Low Genit Tract Dis. 2020;24(2):102-131
7. Stoler MH et al. Gynecologic Oncology. 2019;153(1):26–33
8. Monsonego J et al. Gynecol Oncol. 2015;137(1):47-54
9. Schiffman M et al. Gynecol Oncol. 2015; 138(3):573–578
10. Schiffman M et al. Int. J. Cancer. 2016;139(11):2606–2615
11. Schiffman M et al. J Clin Microbiol.2015;53(1):52-9