How individually identifying HPV 31 can benefit your patients
Cervical Cancer Screening
Not all high-risk HPV genotypes are the same
The 14 most clinically relevant high-risk genotypes, in order of worldwide frequency1, are:
HPV 16, 18, 58, 33, 45, 31, 52, 35, 59, 39, 51, 56, 66 & 68
There are differences not only in the prevalence of the HPV genotypes, but also in the risk of those genotypes to cause cervical cancer.2-4
HPV
HPV 16, 18, 31 and 52
are the most common genotypes in the US5
HPV 31
poses the highest risk for CIN2+ and CIN3+ after HPV 163
HPV 16, 18 and 45
account for 77% of all HPV-positive invasive cancer2
An HPV test with extended genotyping allows for a more comprehensive cervical cancer risk assessment.3,6-10
CIN, cervical intraepithelial neoplasia; HPV, human papillomavirus; US, United States
1. Salazar KL et al. J Am Soc Cytopathol. 2019;8(5):284-292
2. de Sanjose S et al. Lancet Oncol. 2010;11(11):1048-56
3. Stoler MH et al. Gynecologic Oncology. 2019;153(1):26–33
4. Li Y et al. Int J Gynecol Obstet. 2021;152:96–102
5. Monsonego J et al. Gynecol Oncol. 2015;137(1):47-54
6. Elfgren K et al. Am J Obstet Gynecol. 2017;216(3):264.e1-264.e7
7. Radley D et al. Hum Vaccin Immunother. 2016;12(3):768-772
8. Bonde JH et al. J Low Genit Tract Dis. 2020;24(1):1-13
9. Bodily J et al. Trends Microbiol. 2011;19(1):33–39
10. Bonde J et al. Int J Cancer. 2019;145(4):1033-1041